孙钦超,博士,副研究员,博士生导师,深圳市“孔雀计划”海外高层次人才。2016年于日内瓦大学物理化学专业获博士学位,2017-2019年在斯坦福大学从事博士后研究,并于同年加入中国科学院深圳先进技术研究院任副研究员,独立PI。专注于分子荧光探针的发光机理及其在生物医学中的应用,特别是近红外二区(NIR-II)荧光技术的开发与优化。目前取得了多项具有国际影响力的研究成果:发现了首例具有1038 nm荧光峰值波长的第一近红外二区荧光蛋白,这是目前最亮、光稳定性高的NIR-II荧光探针(含有机小分子,无机材料荧光探针),为生物成像领域提供了全新的工具,极大地推动了深层组织成像的研究;首次实现并解释了NIR-II化学发光现象,我们提出了创新性的电子转移机制——“分子轨道秋千模型”,纠正了对这类化学发光机制的传统误解。此理论不仅深化了对化学发光的认识,也为设计新型发光材料提供了理论指导。

  目前以第一作者/通讯作者,发表论文20余篇,其中在 Advanced Functional Materials, Chemical Communication, Journal of physical Chemistry Letters, Chemistry of Materials, Journal of American Chemical Society, Chemical Science,Coordination Chemical Review 等知名期刊上,并获得了国内外同行的高度评价。主持国自然面上项目2项,青年基金1项,深圳市重点项目1项,骨干参与国自然仪器,科技部重点研发计划。

  我们一直坚持用物理化学的方法探索分子荧光的奥秘,并努力将其应用于实际问题解决中,特别是生物医学领域。未来,我将继续带领团队深入探索,力求为科学界贡献更多有价值的研究成果。

  25. Zong Chang, Jianglan Cai, ChenChen Liu, Shubi Zhao, Xiaoping Zhang, Feifei Wang, Qinchao Sun*, Strong Exciton Emission and Ultra-Photostable Near Infrared-II Fluorescent Protein for In Vivo Imaging, Advanced Functional Materials, Adv. Funct. Mater. 2024, 2416366.

  24. Zong Chang, Like Guo, Jianglan Cai, Yang Shu, Jie Ding, Qinchao Sun*, Oxygen Concentration Effect in Photosensitized Generation of 1O2 from Normoxia to Hypoxia, J. Phys. Chem. Lett. 2024, 15, 11126−11130

  23. Fei Xia, David Sinefeld, Zong Chang, Xiaojing Gong*, Qinchao Sun*, Simultaneous 2-photon and 3-photon excitation with a red fluorescent protein-cyanine dye probe pair in the 1700-nm excitation window for deep in vivo neurovascular imaging, Biomedical Optics Express, 2024, 15, 6670-6681

  22. Bingxin Shu, Shubi Zhao, Yuling Zhang, Qinchao Sun*, Zhen Huang *, NIR afterglow nanosystem for photodynamic therapy, RSC Adv., 2024, 14, 22792

  21. Chenchen Liu, Zong Chang, Kailei Chen, Qiang Xue, Bingxin Shu, Zhihao Wei, Xuan Zhou, Like Guo, Yuling Zhang, Yingying Pan, Qi Cao, Huageng Liang, Qinchao Sun* and Xiaoping Zhang*, A mitochondrion-targeted cyanine agent for NIR-II fluorescence-guided surgery combined with intraoperative photothermal therapy to reduce prostate cancer recurrence, Journal of Nanobiotechnology (2024) 22:224

  20. Chenchen Liu, Xiaoming Liu, Zhihao Wei, Zong Chang, Yaowei Bai, Pei Zeng, Qi Cao, Changjun Tie, Ziqiao Lei, Peng Sun, Huageng Liang*, Qinchao Sun*, Xiaoping Zhang*, Amorphous Albumin Gadolinium-Based Nanoparticles for Ultrahigh-Resolution Magnetic Resonance Angiography, ACS Appl. Mater. Interfaces, 2024, 16, 8, 9702–9712

  19.Zhiyi Yang, Zong Chang, Ka Deng, Junjie Gu, Yihao Wu, Qinchao Sun*, Qian Luo*. Reactive Matrices for MALDI-MS of Cholesterol, Analytical Chemistry, 2023, 95, 16786-16790

  18. Zong Chang, Chenchen Liu, Like Guo, Bingxin Shu, Huageng Liang*, Jie Ding*, Xiaoping Zhang*, Qinchao Sun*. Single-dye NIR-II chemiluminescence system for H2O2 imaging, Chemical Communication, 2023,59, 6171-6174

  17. Zong Chang, Liangjian Liu, Jingying Zhai, Chenchen Liu, Xiao Wang, Chengbo Liu, * Xiaojiang Xie, * Qinchao Sun*. Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging, Chemistry of Materials, 2023, 35, 1335-1344.

  16. Zong Chang, Chenchen Liu, Shubi Zhao, Jiaqi Chen, Xiaoping Zhang, Hanyu Tian, Qinchao Sun*, Near Infrared-II Fluorescent protein for In-vivo Imaging, bioRxiv, 2022, 2022.03.04.482971

  15. Qiang Liu, Jiangwei Tian, Ye Tian, Qinchao Sun, Dan Sun, Dewen Liu, Feifei Wang, Haijun Xu, Guoliang Ying, Jigang Wang, Ali K. Yetisen, Nan Jiang, Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy, Acta Biomaterialia, 127, 287-297

  14. Jingqin Chen, Adam C. Sedgwick, Sajal Sen, Yaguang Ren, Qinchao Sun, Calvin Chau, Jonathan F. Arambula, Tridib Sarma*, Liang Song, Jonathan L. Sessler *, Chengbo Liu*, Expanded porphyrins: functional photoacoustic imaging agents that operate in the NIR-II region, Chem. Sci., 2021, 12, 9916-9921

  13. Shubi Zhao#, Yiqun Luo#, Zong Chang, Chenchen Liu, Tong Li, Lu Gan, Yong Huang*, Qinchao Sun*, BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy,Nanoscale Research Letters, 2021, 16, 170.

  12. Qiang Liu#, Jiangwei Tian#, Ye Tian#, Qinchao Sun#, Dan Sun, Feifei Wang, Haijun Xu*, Guoliang Ying*, Jigang Wang*, Ali K. Yetisen, Nan Jiang*, Near-Infrared-II Nanoparticles for Cancer Imaging of Immune Checkpoint Programmed Death-Ligand 1 and Photodynamic/Immune Therapy, ACS Nano 2021, 15, 1, 515–525

  11. Zong Chang#, Feng Liu#, Liang Wang, Mengying Deng, Chunhua Zhou, Qinchao Sun*, Jun Chu*. Near-infrared dyes, nanomaterials and proteins, Chinese Chemical Letters, 2019, 30,1856-1882

  10. Feifei Wang#, Hao Wan#, Zhuoran Ma#, Yeteng Zhong, Qinchao Sun, Ye Tian, Liangqiong Qu, Haotian Du, Mingxi Zhang, Lulin Li, Huilong Ma, Jian Luo, Yongye Liang, Wen Jung Li, Guosong Hong, Lianqing Liu, Hongjie Dai*, Light-sheet microscopy in the near-infrared II window, Nature Methods, 2019, 16, 545-552

  9. Zhuoran Ma#, Hao Wan, Weizhi Wang, Xiaodong Zhang, Takaaki Uno, Qianglai Yang, Jingying Yue, Hongpeng Gao, Yeteng Zhong, Ye Tian, Qinchao Sun, Yongye Liang, Hongjie Dai*, A theranostic agent for cancer therapy and imaging in the second near-infrared window, Nano Research, 2019, 12(2), 273-279

  8. Qinchao Sun#, Bogdan Dereka, Eric Vauthey, Latévi M. Lawson Daku, Andreas Hauser*, Ultrafast transient IR spectroscopy and DFT calculations of ruthenium (II) polypyridyl complexes, Chemical Science. 2017(1), 8, 223-230.

  7. Thomas Biet#, Thomas Cauchy, Qinchao Sun, Jie Ding, Andreas Hauser*, Patric Oulevey, Thomas Bürgi, Denis Jacquemin, Nicolas Vanthuyne, Jeanne Crassous, Narcis Avarvari*, Triplet state CPL active helicene-dithiolene platinum bipyridine complexes. Chemical Communications. 2017, 53(66), 9210-9213.

  6. Qinchao Sun#, Sandra Mosquera-Vazquez, Yan Suffren, Jihane Hankache, Nahid Amstutz, Latévi Max Lawson Daku, Eric Vauthey, Andreas Hauser*, On the role of ligand-field states for the photophysical properties of ruthenium (II) polypyridyl complexes. Coordination Chemistry Reviews. 2015, 282–283, 87-99.

  5. Iuliia Nazarenko#, Flavia Pop, Qinchao Sun, Andreas Hauser, Francesc Lloret, Miguel Julve, Abdelkrim El-Ghayoury, Narcis Avarvari*, Structural, Photophysical and Magnetic Properties of Transition Metal Complexes Based on the Dipicolylamino-chloro-1,2,4,5-tetrazine Ligand. Dalton Transactions. 2015, 44(19), 8855-8866.

  4. Qinchao Sun#, Sandra Mosquera-Vazquez#, Latev́i Max Lawson Daku, Laure Gueńeé, Harold A. Goodwin, Eric Vauthey, Andreas Hauser*, Experimental Evidence of Ultrafast Quenching of the 3MLCT Luminescence in Ruthenium (II) Tris-bipyridyl Complexes via a 3dd State. Journal of American Chemical Society. 2013, 135(37), 13660-13663.

  3. Nikolaos Gomopoulos#, Cornelis Lütgebaucks, Qinchao Sun, Carlos Macias-Romero, Sylvie Roke*, Label-free second harmonic and hyper Rayleigh scattering with high efficiency. Optics Express. 2013, 21(1), 815-821.

  2. Qinchao Sun#, Jianyong Liu*, Yan Hao, Xichuan Yang, Volume-conserved Twist Excited-state of π-Conjugated Molecules. Chinese Journal of Chemical Physics. 2010, 23(6), 637-642.

  1. Qinchao Sun#, DaCheng Feng*, DFT Study and Quantitative Structure-activity Relationship for Cephalosporin Derivatives. Chemical Journal of Chinese Universities. 2007, 28(4), 696-699.

  国自然面上项目,近红外二区荧光蛋白的设计及其活体成像研究, 50 万2024/01-2027/12,主持

  国自然面上项目, 基于近红外二区有机小分子的神经元膜电位探针开发与应用, 63 万,2021/01-2024/12,主持

  国自然青年项目,具有抗癌活性和光学成像功能的稀⼟纳⽶颗粒钌类配合物体系的研究,25万,2020/01-2022/12,主持

  深圳市基础研究重点项目,基于环化重排荧光蛋⽩的红⾊钙离⼦荧光探针研发,212万2020/01-2024/12,主持

  国自然仪器项目,用于早期前列腺癌组织形态与功能研究的光声磁多模态成像系统,444万,2020/01-2022/12,先进院负责人

  国家重点研发计划,多模态自反馈智能驱动神经检测与调控系统,40 万,2025/01-2027/12,骨干参与

  广东省生物医学光学影像技术重点实验室,100 万,2020/01 -2023/12,参与

  孙钦超,于海霞,咪唑吡嗪酮类荧光素及其制备方法CN202110791007.X

  常宗, 孙钦超, 刘郴郴,荧光化合物和探针PCT/CN2021/137625 

  常宗, 孙钦超, 刘郴郴,一种近红外荧光/磁共振双模探针及其制备方法和应用CN202211273204.3