高笃阳,博士,中国科学院深圳先进技术研究院,副研究员,博士生导师,深圳市“孔雀计划”海外高层次人才。主要从事多模态分子影像探针制备及其医学应用研究,主持国家自然科学基金项目,广东省项目多项。在Nature Communications, Advanced Science, Advanced Functioned Material, Small, Theranostics等杂志发表学术论文30余篇,申请专利10余项。

  1. Liu, Yuxia#; Gao, Duyang#(高笃阳); He, uan; Ma, Jing; Chong, Suet Yen; Qi, Xinyi; Ting, Huijun; Luo, Zichao; Yi, Zhigao; Tang, Jingyu; Chang, Chao; Wang, Jiongwei; Sheng, Zonghai*; Zheng, Hairong*; Liu, Xiaogang*, Single-point mutated lanmodulin as a highperformance MRI contrast agent for vascular and kidney imaging. Nature Communications, 2024, 15,9834.

  2. Chen, Zhen#; Huang, Linjian#; Gao, Duyang#(高笃阳); Bao, Zhouzhou*; Hu,Dehong; Zheng,Wei; Chen, Jing*; Liao, Jiuling*; Zheng, Hairong; Sheng, Zonghai*, High Spatiotemporal Near-Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins. Advanced Science, 2024, 2411272.

  3. Zheng, Si#; Gao, Duyang#(高笃阳); Wu, Yayun; Hu, Dehong; Ziyue Li, Wang,Yuenan; Zheng, Hairong*; Li, Yingjia *; Sheng, Zonghai*, X-ray-activatable Au/Ag nanorods for radio-immunooncotherapy sensitization and monitoring of the therapeutic response using NIR-II photoacoustic imaging. Advanced Science, 2023, 2206979.

  4. Gao, Duyang(高笃阳); Luo, Zichao; He, Yang; Yang, Lixiang; Hu, Dehong; Liang,Yongye; Zheng, Hairong*; Liu, Xiaogang*; Sheng, Zonghai*, Low-dose NIR-II preclinical bioimaging using liposome-encapsulated cyanine dyes. Small 2023, 2206544.

  5. Mei, Zihan#; Gao, Duyang#(高笃阳); Hu, Dehong; Zhou, Huichao; Ma, Teng; Huang, Liang; Liu, Xin; Zheng, Rongqin; Zheng, Hairong; Zhao, Ping*; Zhou, Jianqiao*; Sheng, Zonghai*, Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods. Biomaterials 2020, 251, 120092.

  6. Liu, Jing#; Gao, Duyang#(高笃阳); Hu, Dehong; Lan, Siyi; Liu, Yu; Zheng, Hairong*; Yuan, Zhen*; Sheng, Zonghai*, Delivery of biomimetic liposomes via meningeal lymphatic vessels route for targeted therapy of Parkinson’s disease. Research 2023, 6, 0030.

  7. Liu, Yu; Hu,Dehong; Gao, Duyang*(高笃阳); Gong,; Zheng, Hairong; Sun, Minjie*; Sheng, Zonghai*, Engineered apoptotic bodies hitchhiking across the blood-brain barrier achieved a combined photothermal-chemotherapeutic effect against glioma. Theranostics 2023 13(9):2966-2978.

  8. Alimina, Awen#; Hu, Dehong#; Gao, Duyang*(高笃阳); Wang , Zihang; Wu, Yayun; Zheng, Hairong; Guan, Lina; Mu, Yuming *; Sheng, Zonghai*, Dual-Modal Molecular Imaging and Therapeutic Evaluation of Coronary Microvascular Dysfunction using Indocyanine Green-Doped Targeted Microbubbles. Biomaterials Science 2023, 11(7), 2359-2371.

  9. Hou, Bo#; Yi, Luying#; Hu, Dehong; Luo, Zichao; Gao, Duyang(高笃阳); Li, Chao; Xing, Bowen; Wang, Jiong-Wei; Lee, Chuen Neng; Zhang, Rong; Sheng, Zonghai*; Zhou, Bin*; Liu, Xiaogang*, A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy, Nature Biomedical Engineering, 2023, 7, 1242–1251.

  1.国家自然科学基金委员会,青年科学基金项目,IGF1R靶向的白蛋白磁光纳米自组装体的构建及其用于胰腺癌的多模态分子成像研究,2020.01-2022.12,21万,结题,主持

  2.博士后科学基金,博士后基金,构建白蛋白修饰的多模态纳米探针用于胰腺癌早期诊断,2019.01-2020.12,8万,结题,主持

  3.科技部,国家重点研发计划,电流响应型磁共振神经活动成像探针,2023.12-2026.11,530万,在研,参与

  4.广东省基础与应用基础研究基金委员会,广东省自然科学基金-青年提升项目,仿生可激活二区荧光微泡精准可视化心脏微血栓研究, 2024.01-2026.12,30万,在研,主持

  5.广东省科技厅,广东省面上项目,仿生酸性微环境响应磁光双模分子影像探针靶向脑胶质瘤研究, 2023.01-2025.12,10万,在研,主持

  [1]郑海荣,高笃阳,盛宗海,胡德红,聚乙烯吡咯烷酮修饰三氧化二铁磁性团簇及其制备方法和应用,CN115607693A,中国发明专利

  [2]盛宗海,郑海荣,胡德红,高笃阳,刘新,一种用于脑部疾病诊断和治疗的微针系统及其制备方法,CN114948852A,中国发明专利

  [3]郑海荣,盛宗海,高笃阳,胡德红,一种AIE纳米探针的合成方法、AIE纳米探针、试剂盒及其应用,CN114225053A,中国发明专利

  [4]盛宗海,郑海荣,胡德红,高笃阳,吲哚菁绿脂质体及其大规模制备方法和应用,CN114306644A,中国发明专利

  [5]郑海荣,胡德红,罗新平,盛宗海,马腾,高笃阳,一种巨噬细胞示踪荧光探针的制备方法及应用,PCT/CN2020/129547,PCT专利

  [6]郑海荣,盛宗海,耿晓瑞,高笃阳,胡德红,一种用于近红外二区荧光检测的吲哚菁绿脂质体及其制备方法和用途,PCT/CN2020/129545,PCT专利